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李家洋

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李家洋   农业部副部长、党组成员,中国农业科学院院长
  
  
  李家洋,男,1956年7月出生于安徽肥西,植物分子遗传学家。1982年初获安徽农业大学学士学位,1984年获中科院遗传研究所硕士学位,1991年获美国布兰代斯大学博士学位,并进入美国康乃尔大学汤普逊植物研究所从事博士后研究。1994年回国工作,历任中国科学院遗传研究所所长助理、所长,遗传与发育生物学研究所所长。2004年1月任中国科学院党组成员、副院长,2011年10月任农业部副部长、党组成员、中国农业科学院院长。第十八届中央候补委员。
    先后获“国家杰出青年基金”、中国科学院“百人计划”、国家自然科学委员会优秀团队研究基金。1998年享受国务院政府特殊津贴,2001年被评为863计划先进个人,2003年获中央组织部、宣传部、统战部、人事部、教育部与科学技术部联合授予的“留学回国人员成就奖”,2004年获全球华人生物科学家大会生命科学成就奖、何梁何利生命科学奖和中国十大科技新闻人物,2005年获国家自然科学奖二等奖、发展中国家科学院讲演奖、长江学者成就二等奖,2011年获“十一五”国家科技计划执行突出贡献奖、美国植物生物学家协会终身会员奖,2013年获中国科学院2013年度杰出科技成就奖。2001年当选中国科学院院士,2004年当选发展中国家科学院院士,2011年当选美国科学院外籍院士,2012年当选为德国科学院院士,2013年当选欧洲分子生物学组织外籍成员。
    长期从事水稻等植物生长发育与代谢调控的机理研究。主持过多项重大课题研究,在国内外顶尖学术期刊上发表了一系列论文并被广泛引用,成为“世界高被引用科学家”之一。以粮食作物水稻和模式植物拟南芥为材料,研究植物激素的合成途径与作用机理,着重于阐明高等植物株型形成的分子机理,并致力于水稻的分子品种设计,培育高产、优质、高抗、高效新品种。采用图位法克隆水稻分蘖控制基因,开拓了水稻分蘖控制与水稻理想株型分子机理研究的新领域。被汤森路透知识产权与科技集团评为《2014年最具影响力的科研精英》。
    担任农业部副部长、中国农科院院长以来,坚持“顶天立地”的办院方针,注重民主办院与开放办院,坚持民主集中制,发挥班子成员的积极性、主动性和创造性,研究提出“建设世界一流农业科研院所”的发展目标。实施“现代农业科研院所建设行动”,进一步明确院所发展定位,完善所长负责制、职代会、学术委员会等民主决策制度,加强支撑保障。积极争取上级部门支持,推动设立并实施中国农科院科技创新工程,成为继中科院知识创新工程、社科院哲学社会科学创新工程之后第三个国家级创新工程。注重并坚持围绕国家重大需求,加强科研布局与储备性成果培育,组织开展重要作物增产增效综合技术的示范推广与协作攻关。初步构建了分级、分期、分类的研究所、人才团队、学科、重大项目及成果等评价体系,建立创新工程绩效管理制度。积极推进人才工作和研究生教育,探索建立以“人员能进能出、职务能上能下、薪酬能高能低”为核心的人才管理机制,启动实施“青年英才计划”,加强优秀青年人才引进与培养。优化学科平台区域布局,分别启动与深圳市合作共建农业基因组研究所、与大连市合作共建现代都市农业研究所、与新疆维吾尔自治区共建西部农业研究中心。推动在北京市通州区建设中国农科院新院区,拓展京区发展空间。大力推动国内外交流合作,强化与欧盟、拉美、中亚、东盟等地区国家著名科研机构的农业科技合作,推动建立全国农业科技创新联盟,形成科研合力,解决产业重大科技问题。大力开展院区环境整治,努力推动解决全院广大科技人员和干部职工共同关注的热点、难点问题,全院面貌焕然一新。
     
  
近期发表的代表性论文和著作
  
   A. Selected Peer-Reviewed Articles

1. Cardoso C, Zhang Y, Jamil M, Hepworth J, Charnikhova T, Dimkpa S, Meharg C, Wright M, Liu J, Meng X, Wang Y, Li J, McCouch S, Leyser O, Price A, Bouwmeester H and Ruyter-Spira C (2014) Natural variation of rice strigolactone biosynthesis is associated with the deletion of two MAX1 orthologs. Proc Natl Acad Sci USA 111: 2379–2384.
2. Jiang L, Liu X, Xiong G, Liu H, Chen F, Wang L, Meng X, Liu G, Yu H, Yuan Y, Yi W, Zhao L, Ma H, He Y, Wu Z, Melcher K, Qian Q, Xu H, Wang Y and Li J (2013) DWARF 53 acts as a repressor of strigolactone signaling in rice. Nature 504: 401-405.
3. Lu Z, Yu H, Xiong G, Wang J, Jiao Y, Guifu Liu G, Jing Y, Meng X, Hu X, Qian Q, Fu X, Wang Y and Li J (2013) Genome-wide binding analysis of the transcription activator IPA1 reveals a complex network regulating rice plant architecture. Plant Cell 25: 3743-3759.
4. Zhu Y, Guo G, Zhang Z, Liu C, Hu Q, Lam H, Cheng H, Xue Y, Li J and Li N (2013) Stable isotope metabolic labelingbased quantitative phosphorproteomic analysis of Arabidopsis mutants reveals ethyleneregulated time-dependent phosphorproteins and putative substrates of Constitutive Triple Response 1 kinase. Mol Cell Proteomics 12, 3559-3582.
5. Jia G, Huang X, Zhi H, Zhao Y, Zhao Q, Li W, Chai Y, Yang L, Liu K, Lu H, Zhu C, Lu Y, Zhou C, Fan D, Weng Q, Guo Y, Huang T, Zhang L, Lu T, Feng Q, Hao H, Liu H, Lu P, Zhang N, Li Y, Guo E, Wang S, Wang S, Liu J, Zhang W, Chen G, Zhang B, Li W, Wang X, Li H, Zhao B, Li J, Diao X and Han B (2013) A haplotype map of genomic variations and genome-wide association studies of agronomic traits in foxtail millet (Setaria italica). Nature Genet doi:10.1038/ng.2673.
6. Gao Z, Zhao S, He W, Guo L, Wang J, Peng Y, Guo X, Zhang X, Rao Y, Zhang C, Dong G, Zheng F, Lu C, Hu J, Zhou Q, Liu H, Hu X, Xu J, Zeng D, Liu D, Tian P, Gong L, Li Y, Zhang G, Wang J, Tian F, Xue D, Liao Y, Chen M, Li J, Cheng S, Zhang G, Wang J, Qian Q (2013) Uncovering yield-associated loci in super-hybrid rice by resequencing recombinant inbred lines while improving its parental genome sequences. Proc Natl Acad Sci USA 110: 14492-14497.
7. Liu L, Shang-Guan K, Zhang B, Liu X, Yan M,  Lanjun Zhang L, Shi Y, Zhang M, Qian Q, Li J and Zhou Y (2013) Brittle Culm1, a COBRA-Like Protein, Functions in Cellulose Assembly through Binding Cellulose Microfibrils. PLoS Genet 9: e1003704.
8. Zhao L, Zhou X, Wu Z, Yi W, Xu Y, Li S, Xu T, Liu Y, Chen R, Kovach A, Kang Y,  Hou L, He Y, Xie C, Song W, Zhong D, Xu Y, Wang Y, Li J, Zhang C, Melcher K and Xu H (2013) Crystal structures of two phytohormone signal-transducing α/β hydrolases: karrikin-signaling KAI2 and strigolactonesignaling DWARF14. Cell Res 23:436-439.
9. Chen L, Xiong G, Cui X, Yan Y, Xu T, Qian Q, Xue Y, Li J and Wang Y (2013) OsGRAS19 may be a novel component involved in the brassinosteroid signaling pathway in rice. Mol Plant 6: 988-991.
10. Zhang X, Wang J, Huang J, Lan H, Wang C, Yin C, Wu Y, Tang H, Qian Q, Li J, and Zhang H (2012) Rare allele of OsPPKL1 associated with grain length causes extra-large grain and a significant yield increase in rice. Proc Natl Acad Sci USA 109: 21534-21539.
11. Huang X, Kurata N, Wei X, Wang Z, Wang A, Zhao Q, Zhao Y, Lu H, Li W, Guo Y, Lu Y, Liu K, Zhou C, Fan D, Weng Q, Zhu C, Huang T, Zhang L, Wang Y, Feng L, Furuumi H, Kubo T, Miyabayashi T, Yuan X, Xu Q, Dong G, Zhan Q, Li C, Fujiyama A, Toyoda A, Lu T, Feng Q, Qian Q, Li J and Han B (2012) A map of rice genome variation reveals the origin of cultivated rice and domestication-associated genes. Nature 490: 497-502.
12. Xu C, Wang Y, Yu Y, Duan J, Liao L, Xiong G, Meng X, Liu G, Qian Q and Li J (2012) Degradation of MONOCULM 1 (MOC1) by APC/CTAD1 regulates rice tillering. Nature Communications DOI: 10.1038/ncomms1743.
13. Huang X, Zhao Y, Wei X, Li C, Wang A, Zhao Q, Li W, Guo Y, Deng L, Zhu C, Fan D, Lu Y, Weng Q, Liu K, Zhou T, Jing Y, Si L, Dong G, Huang T, Lu T, Feng Q, Qian Q, Li J and Han B (2012) Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm Nature Genet 44: 32-39.
14. Huang Xu, Wei X, Sang T, Zhao Q, Feng Q, Zhao Y, Li C, Zhu C, Lu T, Zhang Z, Li M, Fan D, Guo Y, Wang A, Wang L, Deng L, Li W, Lu Y, Weng Q, Liu K, Huang T, Zhou T, Jing Y, Li W, Lin Z, Bucker ES, Qian Q, Zhang Q, Li J and Han B (2010) Genome-wide association studies of 14 agronomic traits in rice landraces. Nature Genet 42: 961-967.
15. Jiao Y, Wang Y, Xue D, Wang J, Yan M, Liu G, Dong G, Zeng D, Lu Z, Zhu X, Qian Q and Li J (2010) Regulation of OsSPL14 by OsmiR156 defines ideal plant architecture in rice. Nature Genet 42, 541-544.
16. Cui X, Ge C, Wang R, Wang H, Chen W, Fu Z, Jiang X, Li J, Wang Y (2010) The BUD2 mutation affects plant architecture through altering response to cytokinin and auxin in Arabidopsis. Cell Res 20: 576-586.
17. Melcher K, Ng LM, Zhou X, Soon FF, Xu Y, Suino-Powell KM, Park SY, Weiner JJ, Fujii H, Chinnusamy V, Kovach A, Li J, Wang Y, Li J, Peterson FC, Jensen DR, Yong EL, Volkman BF, Cutler SR, Zhu J, and Xu E (2009). A gate-latch-lock mechanism for hormone signalling by abscisic acid receptors. Nature 462: 602-608.
18. Wang H, Zhu Y, Fujioka S, Asami T, Li J, and Li J (2009). Regulation of Arabidopsis brassinosteroid signaling by atypical basic helix-loop-helix proteins. Plant Cell 21: 3781-3791.
19. Lin H, Wang R, Qian Q, Yan M, Meng X, Fu Z, Yan C, Jiang B, Su Z, Li J, and Wang Y (2009). DWARF27, an iron-containing protein required for the biosynthesis of strigolactones, regulates rice tiller bud outgrowth. Plant Cell 21: 1512-1525.
20. Huang X, Qian Q, Liu Z, Sun H, He S, Luo D, Xia G, Chu C, Li J, and Fu X. (2009) Natural variation at the DEP1 locus enhances grain yield in rice. Nat Genet 41: 494-497.
21. Li S, Qian Q, Fu Z, Zeng D, Meng X, Kyozuka J, Maekawa M, Zhu X, Zhang J, Li J and Wang Y (2009) Short panicle1 encodes a putative PTR transporter and determines rice panicle size. Plant J 58: 592-605
22. Zhou Y, Li S, Qian Q, Zeng D, Zhang M, Guo L, Liu XL, Zhang B, Deng L, Liu XF, Luo G, Wang X and Li J (2009) BC10, a DUF266-containing and golgi-located type II membrane protein, is required for cell wall biosynthesis in rice (Oryza sativa L.) Plant J 57: 446-462.
23. Tian Z, Qian Q, Liu Q, Yan M, Liu X, Yan C, Liu G, Gao Z, Tang S, Zeng D, Wang Y, Yu J, Gu M and Li J (2009) Allelic diversities in rice starch biosynthesis lead to a diverse array of rice eating and cooking qualities. Proc Natl Acad Sci USA 106: 21760–21765.
24. Yu Y, Tang T, Qian Q, Wang Y, Yan M, Zeng D, Han B, Wu Chung-I, Shi S and Li J (2008) Independent losses of function in a polyphenol oxidase in rice: differentiation in grain discoloration between subspecies and the role of positive selection under domestication. Plant Cell 20: 2946-2959.
25. Li P, Wang Y, Qian Q, Fu Z, Wang M, Zeng D, Li B, Wang X, and Li J ( (2007) LAZY1 controls rice shoot gravitropism through regulating polar auxin transport. Cell Res 17: 402-410.
26. Dai Y, Wang H, Li B, Huang J, Liu X, Zhou Y, Mou Z and Li J (2006) Increased expression of MAPKK7 causes deficiency in polar auxin transport and leads to plant architectural abnormality in Arabidopsis. Plant Cell 18: 308-320.
27. Xiong G, Hu X, Jiao Y, Yu Y, Chu C, Li J, Qian Q and Wang Y (2006) LEAFY HEAD2, which encodes a putative RNA-binding protein, regulates shoot development of rice. Cell Res 16: 267-276.
28. Ge C, Cui X, Wang Y, Hu Y, Fu Z, Zhang D, Cheng Z, and Li J (2006) BUD2, encoding an S-adenosylmethionine decarboxylase, is required for Arabidopsis growth and development. Cell Res 16: 446-456.
29. Hu Y, Wang Y, Liu X, Li J (2004) Arabidopsis RAV1 is down-regulated by brassinosteroid and may act as a negative regulator during plant development. Cell Res 14: 8-15.
30. Li Y, Qian Q, Zhou Y, Yan M, Sun L, Zhang M, Fu Z, Wang Y, Han B, Pang X, Chen M and Li J (2003) BRITTLE CULM 1, which encodes a COBRA-like protein, affects the mechanical properties of rice plants. Plant Cell 15: 2020-2031.
31. Li X, Qian Q, Fu Z, Wang Y, Xiong G, Zeng D, Wang X, Liu X, Teng S, Hiroshi F, Yuan M, Luo D, Han B and Li J (2003) Control of tillering in rice. Nature 422: 618-621.
32. Feng Q, Zhang Y, Hao P, Wang S, Fu G, Huang Y, Li Y, Zhu J, Liu Y, Hu X, Jia P, Zhang Y, Zhao Q, Ying K, Yu S, Tang Y, Weng Q, Zhang L, Lu Y, Mu J, Lu Y, Zhang LS, Yu Z, Fan D, Liu X, Lu T, Li C, Wu Y, Sun T, Lei H, Li T, Hu H, Guan J, Wu M, Zhang R, Zhou B, Chen Z, Chen L, Jin Z, Wang R, Yin H, Cai Z, Ren S, Lv G, Gu W, Zhu G, Tu Y, Jia J, Zhang Y, Chen J, Kang H, Chen X, Shao C, Sun Y, Hu Q, Zhang X, Zhang W, Wang L, Ding C, Sheng H, Gu J, Chen S, Ni L, Zhu F, Chen W, Lan L, Lai Y, Cheng Z, Gu M, Jiang J, Li J, Hong G, Xue Y and Han B (2002) Sequence and analysis of rice chromosome 4. Nature 420: 316-320.
33. Mou Z, Wang X, Fu Z, Dai Y, Han C, Ouyang J, Bao F, Hu Y, and Li J (2002) Silencing of phosphoethanolamine N-methyltransferase results in temperature-sensitive male sterility and salt hypersensitivity in Arabidopsis. Plant Cell 14: 2031-2043.
34. Hu Y, Bao F and Li J (2000) The promotive effect of brassinosteroids on cell division involves a distinct cycD3-induction pathway in Arabidopsis. Plant J 24: 693-701.
35. Ouyang J, Shao X and Li J (2000) Indole-3-glycerol phosphate, a branchpoint of indole-3-acetic acid biosynthesis from tryptophan biosynthetic pathway in Arabidopsis thaliana. Plant J 24: 327-333.
36. Mou Z, He Y, Dai Y, Liu X and Li J (2000) Deficiency in fatty acid synthase leads to premature cell death and dramatic alterations in plant morphology. Plant Cell 12: 405-417.
37. Li J and Last RL (1996) The Arabidopsis thaliana trp5 mutant has a feedback-resistant anthranilate synthase and elevated soluble tryptophan. Plant Physiol 110: 51-59.
38. Li J, Zhao J, Rose AB, Schmidt R and Last RL (1995) Arabidopsis phosphoribosyl anthranilate isomerase: molecular genetic analysis of triplicate tryptophan pathway genes. Plant Cell 7: 447-461.
39. Li J, Ou-Lee T, Raba R, Amundson RG and Last RL (1993) Arabidopsis flavonoid mutants are hypersensitive to UVB irradiation. Plant Cell 5: 171-179.


B. Selected Invited Articles

1. Zuo J and Li J (2013) Molecular Dissection of Complex Agronomic Traits of Rice: A Team Effort by Chinese Scientists in Recent Years. National Sci Rev doi:10.1093/nsr/nwt004.
2. Li J and Chua N-H (2011) A comprehensive understanding of plant growth and development. Curr Opin Plant Biol 14: 1-3.
3. Wang Y and Li J (2011) Branching in rice. Curr Opin Plant Biol 14: 94-99.
4. Wang Y and Li J (2008). Rice, rising. Nat Genet 40, 1273-1275.
5. Wang Y and Li J (2008). Molecular basis of plant architecture. Annu Rev Plant Biol 59: 253-279.
6. Han B, Xue Y, Li J, Deng X, and Zhang Q (2007) Rice functional genomics research in China. Phil Trans R Soc B 362: 1009–102.
7. Wang Y and Li J (2006) Genes controlling plant architecture. Curr Opin Biotech 17: 123-129.
8. Wang Y, Xue Y and Li J (2005) Towards molecular breeding and improvement of rice in China. Trends Plant Sci 10: 610-614.


C. Selected Invited Book Chapters

1. Sang T and Li J (2013) Molecular genetic basis of the domestication syndrome in cereals. In Cereal Genomics-II (Gupta PK, Varshney RK, eds), Springer Science pp. 319-340.
2. Yu Y, Wing RA and Li J  (2013) Understanding genetic molecular basis of rice grain quality. In Genetics and Genomics of Rice (Zhang Q and Wing RA, eds), Springer New York Heidelberg Dordrecht London, pp. 237-254.
3. Wang Y and Li J (2012) Regulation of plant architecture. In Plant Physiology and Molecular Biology (Chen X, Xue H, eds), Higher Education Press, Beijing, pp. 418-432.
4. Wang Y, Chen M and Li J (2007) Rice. In Biotechnology in Agriculture and Forestry Vol. 59 Transgenic Crops IV (E.C. Pua and M.R.Davey, eds), Springer-Verlag Berlin Heidelberg, pp. 35-54.


  

 


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